In this review, we discussed novel studies that link tau aggregation and neuroinflammation to neurovascular pathologies such as CAA and suggest how the “amyloid–tau–neuroinflammation” axis that has been studied in extensive detail in the context of parenchymal amyloid needs to be dissected in the context of vascular amyloid deposition, as seen in Figure 1. The gene discussed is MAPT; the disease is amyloidosis.