However, not many cellular and molecular studies have been performed to determine the role of tau and neuroinflammation in dementias associated with vascular amyloid accumulation, despite the fact that numerous pathological studies have suggested a preponderant neuroinflammatory response and perivascular tau aggregation in patients and in vivo models for CAA [19,50,95,118,187,188]. The gene discussed is MAPT; the disease is amyloidosis.