It has been reported that not only these inhibitors but also components contained in plant extracts, such as turmeric supplements, Trachelospermi caulis, Moutan cortex radicis, or Saposhnikovia divaricata, can suppress the activation of the classical NF-κB pathway, which mediates excessive immune responses and inflammation followed by cartilage destruction in arthritis [58,59,60,61,62,63,64,65,66]. Here, NFKB1 is linked to arthritic joint disease.