NFKB1 and arthritic joint disease: Moreover, a daily diet of extra-virgin olive oil significantly reduced joint edema and cartilage destruction, preventing arthritis development in a mouse CIA model by suppressing inflammatory cytokines and MMP3 production induced by the Janus kinase signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinases (MAPKs), and the NF-κB pathway [68].