CTNND1 and nonpapillary renal cell carcinoma: In RCC, p120-catenin gene expression is elevated approximately nine-fold in ccRCC patients [54] and, more importantly, there is a correlation between a switch to isoform 1A expression and RCC progression—89.2% of tumors that metastasized over the 5-year follow-up expressed p120-catenin isoform 1A [51].