However, if TIMP-2 is highly produced (like in the case of patients with liver fibrosis, where the level of serum MMP-2 is also high), it can bind to the C terminal region of newly synthesized MMP-2 being transported to the plasma membrane, where this dimer interacts with the membrane-type MMPs, which activates the activity of MMP-2 [7,45,46,47,48]. The gene discussed is TIMP2; the disease is Hepatic fibrosis.