TTR and Hyperglycemia: As evaluated by the Evans Blue (EB) leakage assay, overexpressed TTR repressed diabetes-associated retinal vascular leakage (Figure 1A,B), and the retinal trypsin digestion assay demonstrated that overexpressed TTR partially reversed vascular hyperglycemia-induced pericyte loss and aggravated capillary degeneration (Figure 1C,D).