STAT3 and neoplasm: The activated upstream kinases phosphorylate STAT3 at Tyr705 to undergo dimerization, and translocation into nucleus to transcribe the genes that are involved in proliferation (cyclin D1/E1), inflammation (COX2, IL-1/6 and M-CSF), antiapoptosis (survivin and Bcl-xL), angiogenesis (VEGF, bFGF, and HIF1α), metastasis (MMP2/9), and tumor evasion (IP-10 and RANTES) [19,20,21,22].