The treatment of tumor-bearing mice with IL-15, a cytokine crucial for natural killer (NK), NK and memory (m) CD8+ (cluster of differentiation 8) T-cell function and homeostasis, in addition to JAKi, caused an increase in NK cell population and a reduction in metastases, preventing the JAKi-mediated increase in metastases [80]. Here, CD8A is linked to neoplasm.