In addition, similar results were observed in vivo using a nude mice model injected into the tibia with metastatic breast cancer cells and treated via neutralizing IL-8 [52] or knockdown of osterix [29], a zinc finger-containing transcription factor essential for osteoblast differentiation and bone formation, suggesting a novel and attractive target for the control of bone metastasis of breast cancers [29]. Here, SP7 is linked to breast cancer.