As reported in Table 1 and references therein, in the 67 preclinical articles extracted in this review, several ILs, i.e., IL-1β, IL-2, IL-6, IL-8, IL-10, IL-11, IL-15, IL-17, IL-18, and IL-20 were linked with breast cancer cells homing to bone. This evidence concerns the gene IL2 and breast cancer.