This is supported by findings that patients with prolactinoma have suppressed osteocalcin, high NTX (collagen type I crosslinked N-telopeptide), and increased RANKL (receptor activator of nuclear factor-kB ligand)/OPG (osteoprotegerin) ratio, suggesting increased bone resorption and decreased bone formation [77,78]. Here, TNFRSF11B is linked to prolactin-producing pituitary gland adenoma.