PKM and cancer: Briefly, in the first step, some receptors (e.g., EGFR) trigger the signalling pathway that leads to the enhanced activity of tyrosine kinase and tyrosine phosphorylation of PDHK1 in mitochondria (partially in the nucleus) and PKM2 in cytosol of cancer cells that results in the modification of pyruvate and acetyl-CoA fates compared to the normal cells.