Also, we have previously reinforced that patients with NAFLD/NASH have a high plasmatic level of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), so a potential cytokines imbalance (not evaluated in the present study) could interfere also with the serum concentration of PON1 [35]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatotic liver disease.