In this study, we report the first time that small molecule, 4MU, which downregulates mRNA level and protein expression of FSTL1 in the settings of family (also experimental liver fibrosis conditional knockout of FSTL1 in fibroblasts demonstrated its essential role in cardiac fibroblast activation during cardiac muscle repair after ischemic injury) [24]. This evidence concerns the gene FSTL1 and Hepatic fibrosis.