The disruption of TLR signaling pathway induced by live virulent E. coli and E. coli-derived LPS in pigs by CD14 neutralization antibodies resulted in decreased levels of pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α, and lower granulocyte activation in a pig model of sepsis [88]. This evidence concerns the gene CD14 and Sepsis.