A clinical trial (ClinicalTrials.gov Identifier: NCT03271047) testing the efficacy of combining the MEK inhibitor binimetinib with anti-PD-1 or anti-CTLA-4 agents (nivolumab/ipilimumab) is currently ongoing for cases of pretreated microsatellite stable metastatic CRC patients that harbor a RAS mutation. This evidence concerns the gene PDCD1 and colorectal carcinoma.