This is a rare finding in low‐grade EEC, as it is reported in 2–15% of glandular EEC with low nuclear grade,5, 6, 21, 29, 44, 45 whereas it is a more common finding (10–15%) in high‐grade EECs.36 Two examples of low‐grade EEC with TP53 mutations and abnormal p53‐IHC are shown in Figure 4. This evidence concerns the gene TP53 and exstrophy-epispadias complex.