The results of our pilot study suggest that the total entropy of the HLA and KIR systems may also be capable of associating the HLA and KIR profile of a subject with the risk of developing other diseases with an immune-mediated pathogenesis such as type 1 diabetes, Hashimoto’s thyroiditis, celiac disease, psoriasis, rheumatoid arthritis and systemic lupus erythematosus. This evidence concerns the gene KIR3DL1 and rheumatoid arthritis.