FZD1 and central nervous system cancer: To further emphasize the contribution of glial Fz1 receptor as mediator for neuronal-Wg depletion, we generated glioma cells while silencing Fz1 expression, and, in addition, we co-expressed a constitutively active form of armadillo (UAS-armS10) [68], which activates Wg pathway downstream Wg-Fz1 in these glioma cells (Fig 4D).