Beyond its role in organogenesis and differentiation (De Felice & Di Lauro 2004, Fernandez et al. 2015), FOXE1 has been described as being strongly associated with susceptibility to several types of cancer (Brune et al. 2008, Venza et al. 2010, Park et al. 2012) including PTC (Gudmundsson et al. 2009, Landa et al. 2009, Bullock et al. 2012, He et al. 2015a). The gene discussed is FOXE1; the disease is cancer.