FOXE1 and cancer: Taken all this together, we postulate that FOXE1 has a crucial role in thyroid tumor cell migration and invasion, as shown by the results of loss/gain-of-function of FOXE1 on migration/invasion, and with the increasing evidence of the role of forkhead box proteins in the development and progression of cancer (Myatt & Lam 2007, Katoh et al. 2013).