The role of Foxe1 in development and differentiation is well understood (Santisteban et al. 1992, Aza-Blanc et al. 1993, Ortiz et al. 1997, 1999, De Felice et al. 1998, De Felice & Di Lauro 2004, Fernandez et al. 2015, Lopez-Marquez et al. 2019), yet little is known about its potential role in thyroid carcinogenesis, or how different allelic variants in or near FOXE1 are associated with thyroid cancer risk. Here, FOXE1 is linked to thyroid cancer.