There is biological plausibility for the top gene–disease associations for each disease in Table 5: the gene AGT (angiotensinogen) is implicated in both Alzheimer’s disease (Mateos et al., 2011) and breast cancer (Herr et al., 2008), with evidence that the renin-angiotensin system of which it is a part may be closely involved in cancer processes (Wegman-Ostrosky et al., 2015) and may even be a target for the treatment of cancer (Vallejo-Ardila et al., 2018). This evidence concerns the gene AGT and early-onset autosomal dominant Alzheimer disease.