In contrast with Reincke et al. [10], Ma et al. [11] have investigated a larger cohort of corticotroph adenomas leading to the identification of 17 types of USP8 mutations in the exon encoding the 14-3-3 binding region and of 3 prevalent mutations leading to the expression of USP8 variants, which proved to be most efficient in their ability to deubiquitinate the EGFR in the study of Reincke et al. [10]. The gene discussed is USP8; the disease is ACTH-producing pituitary gland adenoma.