10 More importantly, WT1 inhibits the expression of E‐cadherin through directly binding its promoter to enhance the metastasis.7, 11 All these reports suggest that ectopic expression of WT1 contributes to the pathogenesis of cancer and provides a potential candidate target for therapy. Therefore, inhibition of WT1 gene by siRNA or degradation of WT1 protein by small molecular compounds such as curcumin12 presents anti‐cancer activity in pancreatic cancer. The gene discussed is CDH1; the disease is familial pancreatic carcinoma.