The decreased E‐cadherin expression promotes the metastasis during early carcinogenesis progression.13 The expression of E‐cadherin is complicatedly regulated by many transcript factors, such as ZEB1/2 and Snail, which are induced by multiple signalling pathways including Wnt, TGF‐β and Notch.14 More importantly, E‐cadherin is negatively regulated by WT1.9 Thus, WT1‐E‐cadherin signalling pathway facilitates the metastasis in cancer cells. The gene discussed is CDH1; the disease is cancer.