HLA-DRB1 and rheumatoid arthritis: One of them, that is, HLA‐DQα1:160 D, conferred strong susceptibility to ACPA‐positive RA and another one, HLA‐DRβ1:37N appeared to be protective.176 By using computational modeling, the authors suggested a possible role of these factors in antigen recognition by respective HLA‐typed T cells and their subsequent activation.