CDKN2A and benign prostatic hyperplasia: Clearance of p16‐positive senescent cells delayed age‐associated functional decline in a mouse model.10 Senescence‐associated β‐galactosidase (SA‐βGal) activity at pH 6.0 is another marker for senescent cells.7 Cells of the BPH epithelium and late‐passage epithelial cells isolated from the normal prostate transition zone showed elevated p16/INK4a and SA‐βGal.6, 11, 12 The tumor‐suppressive potential of senescent cells is mitigated in some contexts by a senescence‐associated secretory phenotype (SASP).