In view of a role for STAT5 in stimulating cell proliferation due to cyclin D1 induction,21 and roles of AKT and ERK1/2 in promoting proliferation, growth, and survival of cells,22, 23 we conclude that all three signaling pathways play roles in enhancing BPH‐1 cell growth and proliferation in the presence of SASP‐derived secreted factors. This evidence concerns the gene MAPK3 and benign prostatic hyperplasia.