(1) Grem2 is located on Chr 1 in both mouse and human and overlaps an association for BMD on Chr 1 spanning from 240.1 to 241.1 Mb.5Grem2 is a member of a family of bone morphogenic protein antagonists expressed in bone that has been linked to low BMD.57, 58 (2) Cadm1 is a cell adhesion molecule downregulated in many cancers.59Cadm1 in human overlaps an association for estimated BMD. The gene discussed is GREM2; the disease is cancer.