In patients with acromegaly, GH levels decreased from 8.2 (4.5, 22.9) μg/L to 1.0 (0.5, 2.8) μg/L and IGF‐1 from 113 (86, 139) nmol/L to 3023, 31 nmol/L (all p < 0.001) from baseline to 1‐year PO, as expected. Here, GH1 is linked to acromegaly.