A recent study has reported the methylation and gene expression profiling of B-cell acute lymphoblastic leukemia (ALL) using next-generation sequencing and showed that KBTBD11 differed in methylation and expression levels between two subtypes of patients (TCF3-HLF and TCF3-PBX1) based on the presence of chromosomal translocations [27]. The gene discussed is TCF3; the disease is acute lymphoblastic leukemia.