Additionally, KEGG and GO enrichment analysis were performed and we found that these genes were closely associated with spliceosomal complex, cell adhesion molecule binding, actin cytoskeleton reorganization, base excision repair, etc. From the above mentioned, UBB, UBE2D3 and SF3A1 as the hub genes in this gene interaction network and may be potential targets for the prevention and treatment of HCC in the future. This evidence concerns the gene UBB and hepatocellular carcinoma.