Amyloid-β peptides (AβPs) are generated through sequential cleavage of amyloid precursor protein (APP) by beta-site amyloid cleaving enzyme (BACE)1 and γ-secretase (presenilin-1 (PS1)), which play pivotal roles in AD pathogenesis (Querfurth & LaFerla, 2010). Here, PSEN1 is linked to Alzheimer disease.