However, when BC patients were over 51 years of age, there were no statistically significant differences in EGR1 mRNA expression, and EGR2/3/4 expression levels were significantly downregulated (EGR2: p = 0.0387, EGR3: p = 0.002; EGR4, p = 0.0285). This evidence concerns the gene EGR3 and breast cancer.