Zhang et al. (2017) and Wei et al. (2018) had analyzed the TARGET-NBL dataset in succession and proposed the immune suppressive microenvironment in NB; nevertheless, the former believed that CD4+ T-cells (Th2 subtype) were related to the favorable survival regardless of the MYCN status, whereas the latter suggested that the enhanced activation of NK cells, cytotoxic T lymphocytes (CTL), and cytolytic signatures were associated with superior survival. This evidence concerns the gene MYCN and neuroblastoma.