SMARCA4 and ovarian neoplasm: However, recent publications identified alterations in the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodelling gene, SMARCA4, encoding BRG1, in SCCOHT tumours.7–10 In fact, among ovarian tumours, SMARCA4 mutations are highly specific for SCCOHT tumours as mutations have been demonstrated in 85–100% of the tumours and are correlated with a complete loss of SMARCA4 protein detection by immunohistochemistry (IHC).9,11–15