The integrin α3 and β1 (hereafter α3β1-integrin) complex with CD151 (expressed specifically on intravasating tumor cells) is essential to initiate and maintains a tight interaction with the extracellular matrices (ECMs); e.g., laminin I (LMN I), collagen IV (COL IV) and fibronectin (FN) on the basal side of endothelial cells of the vessel61–63. This evidence concerns the gene FN1 and neoplasm.