In support of this suggestion, DLBCL with MYC/BCL2-DH(TH) and those with BCL2-SH also harboured an additional mutation profile (MYC, GNA13, TP53, P2RY8, PIM1, CCND3, B2M, EBF1 and S1PR2), which was associated with high-grade transformation of FL as shown by several previous studies (Fig. 2b) [38–41]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.