By comparing the overall survival (OS) and progression-free survival (PFS) of the two groups of patients, we observed that the median OS and PFS of patients in the high LINC00459 expression group are much higher than those of patients in the low LINC00459 expression group, which shows that LINC00459 has promising clinical value for the prognosis of melanoma. Here, LINC00459 is linked to melanoma.