In isolated mammary epithelial cells (MECs) from spontaneous breast cancer mice, high TRIB3 or Trib3 expression was found in the CD24+CD29low subpopulation (Fig. 1f, g) and CD24+CD90+ stem-like subpopulation (Supplementary Fig. 1i) from mice with luminal-type MMTV-PyMT breast cancer, in the CD24+CD29high subpopulation from mice with her2-type MMTV-ErbB2 breast cancer (Fig. 1h, i), and in the CD68+ tumor-associated macrophage (TAM) adjacent area in breast cancer patients (Supplementary Fig. 1j). Here, ERBB2 is linked to neoplasm.