Three predicted damaging missense mutations identified in individuals with schizophrenia and located within ‘key’ ligand binding (GluK2 K525E) and transmembrane (GluK4 L825W; GluK4 Y555N) domains of GluK2 and GluK4 subunits, were examined using in silico modelling tools. This evidence concerns the gene GRIK2 and schizophrenia.