LEP and cancer: In the two lines of cancer triple negative marker an increase in cell proliferation was identified when stimulated with leptin, which suggests that as in the cell line MCF 7, leptin participates activating signaling pathways that give this cell type greater proliferative capacity, one of these pathways is related to Wnt/β-catenin, which is key in the development of several types of cancer, since Wnt/β-catenin signal transduction fulfills fundamental functions in the regulation of the proliferation and differentiation of cancer cells.