LEP and obesity due to melanocortin 4 receptor deficiency: There are different mechanisms by which obesity has been linked to cancer, among which are the promotion of inflammation and angiogenesis through the release of some molecules by adipocytes such as fibroblast growth factor (FGF2), angiopoietin-2, angiostatin, endostatin, thrombospondin (TSP-1), resistin, and elevated levels of adipokines such as leptin, among others5.