LEPR and hepatocellular carcinoma: In the HCC 1937 cell line, a decrease in ObR expression was found in all stimulation cases compared to the control, this is due to the fact that upon finding a higher expression of the ObR protein in this cell line, mRNA expression is diminished, whereas for the MDA MB 231 cell line the ObR amplification was not identified by qPCR, this is because the probe used does not amplify the desired sequence in this cell line, since it is focused on the detection of ObRb, which by RT-PCR was determined in MCF 7 and HCC1937 cell lines, but was not detected in MDA MB 231.