It is important to note that in this study it was determined that in the three cell lines a higher concentration of ObR protein expression is observed when stimulated with tamoxifen, this probably corresponds to the ability of ER positive (MCF 7) and triple negative marker cells (HCC 1937 and MDA MB 231) to increase the expression of ObR as a survival mechanism against the damage caused by the chemotherapeutic agent20,21. The gene discussed is ESR1; the disease is hepatocellular carcinoma.