The STAT5 or PI3K-AKT activity-enhancing function by glutathione-depletion has not been described for T cells so far, but upregulated ROS enhanced STAT5-phosphorylation and PI3K-AKT-activity in hepatocytes in the context of obesity and type II diabetes60 or cancer cells61,62. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.