We then analyzed microRNA (miRNA) transcriptional targets of STAT327, and observed increased miR-21 (Fig. 2e) and miR-181b (Supplementary Fig. 2) in tumor samples carrying mutations in PTPRT or JAK2, while non STAT3 targets, such as miR-126, were similar (Supplementary Fig. 3). Here, PTPRT is linked to neoplasm.