The situation outlined above for ATP2B4 is reminiscent of the well-known mutation at the Duffy blood group locus (DARC/ACKR1), which protects against Plasmodium vivax malaria by preventing erythrocytic expression of the Duffy antigen receptor through disruption of a GATA1-binding site46,47. This evidence concerns the gene ACKR1 and Plasmodium vivax malaria.