Furthermore, high expression of phospho-Y523-PSPC1 and nuclear PTK6 in the IHC analysis of human HCC samples was associated with better patient survival compared to low expression of either one of them, as demonstrated by Kaplan–Meier analysis (Fig. 5g, h, p = 0.0021 and p = 0.028, respectively). This evidence concerns the gene PTK6 and hepatocellular carcinoma.