PSPC1 enhances epithelial–mesenchymal transition (EMT), stemness and tumor growth through the activation of core transcription factors (TFs), such as EMT-TFs (e.g., Snail, Slug, and Twist), cancer stem-like cells (CSC)-TFs (e.g., Oct4, Nanog, and Sox2), and c-Myc4. This evidence concerns the gene PSPC1 and neoplasm.