Since upregulated-PSPC1 switches its binding partner from PTK6 to β-catenin during HCC tumor progression, future examination of the participation of PSPC1 in and the inhibitory effects of PSPC1-CT131 on Hippo oncogenic pathway is warranted for exploring potential therapeutic intervention to prolong HCC patient survival. This evidence concerns the gene PSPC1 and hepatocellular carcinoma.