In summary, our data indicated that PSPC1-CT131 interacted with PSPC1 and PTK6 in the nucleus to suppress synergistic oncogenic PSPC1/PTK6 signaling and abolished Wnt3a and TGF-β1 autocrine signaling to abrogate tumor progression (Fig. 8a–c for the hypothetical model and Supplementary Fig. 7h). Here, TGFB1 is linked to neoplasm.