PSPC1 upregulation or PSPC1-Y523F mutation loses nuclear sequestration of tumor suppressive PTK6 to promote cancer EMT, stemness and metastasis via oncogenic cytoplasmic translocation of PTK6 and nuclear translocation of β-catenin, which interacts with PSPC1 to promote Wnt3a autocrine signaling. The gene discussed is PTK6; the disease is neoplasm.