In addition, the concordant high expression of nuclear PTK6 and p-Y523-PSPC1 in lower grade HCC is associated with better survival of HCC patients, indicating that high expression of p-Y523-PSPC1 is a favorable prognostic biomarker for HCC patients and reflects the tumor suppressive function of PTK6 at early stages of HCC. The gene discussed is PTK6; the disease is neoplasm.