Since PSPC1 also elicits EMT and stemness functions4, we postulate that the PSPC1-Y523F-induced redistribution of PTK6 could not only switch the function of PTK6 from tumor suppression to tumor promotion but also facilitate a synergism between the oncogenic PTK6 and PSPC1-Y523F. The gene discussed is PSPC1; the disease is neoplasm.