XPO1 and cancer: For example, Selinexor (KPT-330), a selective inhibitor of nuclear export (SINE) that targets CRM1 (chromosome region maintenance 1 protein, exportin 1 or XPO1), has been under intensive clinical trials either in monotherapy or in combined therapy with other therapeutic agents in diverse cancer types and has shown selective anticancer activity to cancer cells while sparing normal cells24,45.