We selected 30 tumor progression-enriched gene signatures downstream of PSPC1 and PTK6 signaling pathways4,7,34–38 (Supplementary Table 2) to demonstrate the significant up-regulation (in red) and down-regulation (in green) of gene expression under PSPC1/PTK6 dynamic interaction and PSPC1-CT131 treatment. Here, PTK6 is linked to neoplasm.