EIF4E and melanoma: We further evaluated the sensitivity of melanoma persister cell to three other translation initiation inhibitors, including 4E1RCat, a specific inhibitor that disrupts the eIF4E–eIF4G interaction in the eIF4F complex; hippuristanol, a compound that prevents eIF4A from binding to mRNA; and pateamine A, an inhibitor that leads to depletion of eIF4A from the eIF4F complex.