BIRC3 and neoplasm: We explored alterations in additional genes contributing to dysregulation of multiple pathways such as WNT or NF-kB signaling including genes CYLD at 16q12.1, BIRC2 and BIRC3 at 11q22,2, NFKB1 at 4q24, NFKB2 at 10q24.32, TRAF2 at 9q34.3, TRAF3 at 14q32.32 and MAP3K14/NIK at 17q21.31 or other tumor suppressor genes such as CDKN2C (p18) at 1p32.3 or TENT5C/FAM46C at 1p1233,34 (Table 5, Fig. 3).