Recurrent primary MM cytogenetic abnormalities identified by FISH in samples 1–65 were t(11;14) (21.4%), t(4;14) (11.4%), t(14;16) (5.7%), t(14;20) (5.7%), t(6;14) (2.9%), and hyperdiploidy (45.7%) either without an IGH rearrangement (32.9%) or with an IGH rearrangement that did not involve CCND1, FGFR3, MAF, MAFB or CCND3 (12.9%) (Tables 1, 2). This evidence concerns the gene MAF and Miyoshi myopathy.