NRG1 and neoplasm: The differential expression of the above three genes in tumor and normal tissues was further validated in the Gene Expression Profiling Interactive Analysis (GEPIA) database, which included 163 GBM samples and 207 normal samples, revealing that ITGA3 was significantly upregulated but NRG1 and MAP1LC3A were significantly downregulated in GBM tissues (Figure 2A–2C) [20].