Subsequent multivariate Cox regression analysis indicated that only 3 genes—Neuregulin 1 (NRG1, HR 1.142, P=0.008), Integrin Subunit Alpha 3 (ITGA3, HR 1.149, P=0.043), and Microtubule-Associated Protein 1 Light Chain 3 Alpha (MAP1LC3A, HR 1.308, P=0.014)—exhibited significant prognostic value for GBM (Supplementary Table 1). This evidence concerns the gene NRG1 and glioblastoma.