CASP1 and Cognitive impairment: The idea of an important role of neuroinflammation in cognitive deficits is consistent with recent studies showing that inflammatory Casp1 inhibitors, elimination of Casp1 gene expression by knock down or siRNAs, or elimination of Casp1-activating inflammasome pathways, reverse inflammation and cognitive deficits in AD mice models [15, 22, 47, 51].