TARDBP and amyotrophic lateral sclerosis: Finally, while GA aggregates do not strongly correlate with neurodegeneration, or TDP-43 pathology [58], it cannot be excluded that specific forms of GA, e.g., oligomers or aggregates of a specific size, potentially not detected by inclusion staining, may correlate better with ALS/FTD neurodegeneration and TDP-43 pathology than the overall burden of GA aggregates.