These TECs are active in the production of profibrogenic signals, such as transforming growth factor-β (TGF-β), c-jun NH2-terminal kinase (JNK), and epidermal growth factor receptor (EGFR), which provide a pathophysiological link between AKI and CKD [35, 69, 70]. The gene discussed is TGFB1; the disease is chronic kidney disease.