It has also been shown that increase in LDHA can mediate resistance to Aβ toxicity through upregulation of aerobic glycolysis as a protective mechanism, but it is possible that this effect is present in the prodromal stages of AD [50], while at a later stages of the disease aerobic glycolysis and elevated lactate production may contribute to the cognitive decline associated with AD [28]. The gene discussed is LDHA; the disease is Alzheimer disease.