DZ2002 significantly reduced mRNA expression of iNOS and IL-12p40; established polarization markers for M1 macrophages, also to chitinase 3-like 3 (Ym-1) and Arg-1; and established polarization markers for M2 macrophages, in the skin lesions of BLM-induced mice (Fig. 4a, b). The gene discussed is ARG1; the disease is Bloom syndrome.