In the current study, we demonstrated that AML cell-released exosomes targeted HSCs and delivered miR-4532 into HSCs to activate the STAT3 signaling pathway by targeting LDOC1 gene, thus inhibiting normal hematopoiesis, as evidenced by increased DKK1 and decreased colony formation of CD34+ HSCs. Here, DKK1 is linked to acute myeloid leukemia.