Normally, the frequency of IgE-binding to the allergen in sera from an allergic population is used to determine the relative importance of the individual house dust mite allergens, and the equivalent increased IL-5 response of PBMC to group 7 and group 1 allergen (different IgE-inducing activity) indicates that allergens may be equally capable of contributing to an asthmatic response by inducing eosinophilia [73]. Here, IGHE is linked to Increased total eosinophil count.